Solid Organ Transplants Lead to Increased Cancer Rates

"Patients who receive solid organ transplants — a lifesaving treatment associated with substantial morbidity from immunosuppressive therapy — have a doubled cancer risk compared with the population as a whole, a large cohort study determined.

Among recipients of kidney, liver, heart, and lung transplants, the overall standardized incidence ratio (SIR) for malignancy was 2.10 (95% CI 2.06 to 2.14), according to Eric A. Engels, MD, of the National Cancer Institute in Rockville, Md., and colleagues.

The incidence of cancer in these patients was 1,375 per 100,000 person-years, with an excess absolute risk (EAR) attributable to transplantation of 719.3 (95% CI 693.3 to 745.6) per 100,000 person-years, or about 0.7% per year, the researchers reported in the Nov. 2¬†Journal of the American Medical Association.

Malignancy is a recognized complication following solid organ transplantation, but most previous studies investigating this have been small and limited to kidney transplants.”

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  1. missmdisme posted this